by Jeffrey Dach MD
For many years, Stephen Sinatra believed in statin drugs and prescribed them as a cardiologist in Connecticut. He gave lectures to other cardiologists on the merits of statin drugs at medical meetings on behalf of the drug companies. However, after a time, he became disillusioned and was transformed him from a “Statin Choirboy” to a “Statin Disbeliever”.
Dr. Stephen Sinatra’s Observations:
1) many patients with low cholesterol will go on to develop heart disease.
2) In many patients with cholesterol above 280, angiograms show normal coronary arteries. They don’t have heart disease.
3) Population studies discredit cholesterol. For example, the French have the highest cholesterol levels in Europe of 250, and they also have lowest incidence of heart disease. On the Greek Island of Crete, average cholesterol is well over 200, yet there was not a single heart attack there in ten years.
4) Half of all heart attacks occur in people with normal total cholesterol.
Cholesterol and statins
I refer you to Dr. Stephen Sinatra’s excellent article in the Townsend Letter in which he remarks that drug companies Merck and Pfizer have transformed the medical profession into one big vending machine for statin drugs.(4)
The Old Lipid Panel is Obsolete
Dr. Stephen Sinatra also tells us that the old Cholesterol blood test ordered by your primary care doctor is now obsolete, and has been replaced by the more sophisticated lipoprotein panel, providing a wealth of more information. What is this added information? In addition, the Calcium Score is more sensitive and accurate test than serum cholesterol for determining heart disease risk.
LDL Particles – Not All Sizes are Equal
Firstly, the new test provides LDL particle size. Small LDL particle size is the dangerous one associated with increased risk of heart disease. Large buoyant LDL particle size is the safe one, with less heart disease risk. Secondly the Lipoprotein profile includes Lipoprotein (a), a marker of high risk for heart disease risk.
Significance of Total Cholesterol
Steven Sinatra says total cholesterol doesn’t mean much unless you have a level over 320 which increases risk of stroke. Reducing cholesterol can be accomplished with weight reduction and increasing dietary fiber. Dr Sinatra would not prescribe a statin drug unless you are a male with documented heart disease.
Dr. Sinatra says that low LDL below 80 is associated with adverse side adverse side effects of cancer, aggression, cerebral bleeding, amnesia, and immune dysfunction.
Just Don’t Do It
Below you will find Steven Sinatra’s advice if your doctor tells you to take statin based on the standard cholesterol panel:
1) Don’t do it. Ask for a Lipo-protein Subfraction Test such as the NMR LipoPorfile (LabCorp) or Cardio-IQ (Quest)
2) If you are a 50-75 year old male with small dense LDL, then go for the statin drug. It’s a good idea. If you are over 75, don’t take a statin drug as the drugs cause increased mortality in the elderly.
3) If you are a woman, avoid statins, as no statin drug study has ever shown a benefit in all-cause mortality for women by lowering cholesterol, and adverse effects of the drugs are horrendous.
The Greatest Scientific Deception of the Century
Data from the Framingham Study was the basis for the cholesterol theory of heart disease, the theory that elevated cholesterol levels causes heart disease, and reducing cholesterol levels with diet or drugs prevented heart disease. A Biochemist and participant in the Framingham study, George V. Mann, later said in his memoirs,
” Saturated fat and cholesterol in the diet are not the causes of coronary heart disease. That myth is the greatest scientific deception of this century, perhaps of any century.”(7,8)
I Stopped My Statin Drug – Now What ?
What replaces the statin drugs once patients gets off? What lifestyle modifications and nutritional supplements are used to prevent or reverse heart disease? There is an entire program devoted to this called is the Track Your Plaque Program devised by William Davis MD, a Wisconsin cardiologist .
William Davis MD Warns About the Evil Trio
If total cholesterol is not useful as a predictor of heart disease risk, what is? Which lipoprotein markers are the ones to look for? Davis tells us the lipoprotein profile sometimes reveals an evil trio of abnormalities strongly predictive of heart disease, often leading to advanced heart disease at an early age.(6)
Here is the evil trio:
1) Low HDL–generally less than 50 mg/dl.
2) Small Particle Size LDL–especially if 50% or more of total LDL.
3) Lipoprotein(a)–an aggressive risk factor by itself.
If you have the evil trio, rather than robotically prescribe a statin drug, Davis recommends lifestyle modification and dietary supplements. Davis remarks that some of his greatest heart disease reversals have been in patient with this evil trio, which responds well to the regimen listed below. Reversal of Heart disease is determined by reduction in coronary calcium score (or less of an increase).
Here is Dr Davis’ program for Reversing Heart Disease and the Evil Trio
1) Niacin–increases HDL, reduces small LDL, and reduces Lp(a)
2) Elimination of wheat, cornstarch, and sugars–Best for reducing small LDL; less potent for Lp(a) reduction.
3) High-fat intake–Like niacin, effective for all three.
4) High-dose fish oil–Higher doses of EPA + DHA 3000 mg per day.
Here are a cases from the office of people on statins that I see very day. Statin Case Reports From the Office:
Number One – Chronic Psoriatic Rash from Statins:
Dan is about 65 with no history of heart disease and has been on a statin drug for a cholesterol of 220 about two years. His major problem is a red raised rash on his forearms, and hands and forehead which looks a lot like psoriasis, present for about 2 years. Dermatologists have been stumped and of no help.
Dan’s Lipoprotein Profile show large buoyant LDL particles indicating low risk for heart disease. His coronary calcium score was 75th per centile indicating only mildly above average risk of heart disease (50% per centile is average risk).
I told Dan that the rash was most likely a reaction to the statin anti-cholesterol drug, and advised a two week trial off the drug to see if the rash resolves. Three weeks later Dan returns to the office, and reports the skin rash is gone.
Number Two- Lupus-like Skin Lesion from Statins
Sarah is an 82 year old with no history of heart disease and on a statin drug for a cholesterol of 235. She had been to the dermatologist because of skin lesions on her face near the temple areas which were biopsied and reported by the pathologist as inflammation in the skin suggestive of lupus erythematosis. Sarah is concerned she has Lupus and cam to see me for a second opinion. I told Sarah she did not have Lupus and advised her that the skin eruptions were a reaction to the statin drug. Sarah stopped the statin drug and three weeks later reported the skin had returned to normal.
Number Three- Early Alzheimer’s from Statins
Lori is a 52 year old post menopausal with chief complaint of memory loss, cognitive dysfunction and severe fatigue. She had no history of heart disease and been on a statin drug for many years for a cholesterol of 230. I advised her to stop the statin drug. However, her cognitive dysfunction and memory loss continued unchanged. She was unable to find the office for a follow up visit, gave up and drove home.
A study by Muldoon showed virtual 100% of patients on statin drugs have some element of cognitive impairment, ranging from mild to severe symptoms of amnesia and cognitive dysfunction. (5) I have found this to be the case in actual clinical practice.
Number Four- Wheelchair bound non-healing deep infections from statins
Jim is a war veteran and was paralyzed from a roadside bomb many years ago, and has since been wheelchair bound. Although there is no history of heart disease, his doctor placed him on a statin drug for a cholesterol of 245 about two years ago. Shortly thereafter, Jim developed non-healing chronic decubitus infections at the ischial tuberosities at the site of pressure sitting in the wheelchair. Jim has had numerous surgical procedure and drainages, debridements, and multiple courses of antibiotics for these chronic infections which refuse to heal. In this case, the statin drug prevents healing of chronic infection. Jim stopped the statin drug, began an intensive nutritional program to boost immunity and healing ability and reported improvement after 6 weeks.
Credit and Thanks to Stephen Sinatra MD and William Davis MD for most of the information in this article.
Articles with Related Interest:
If we have to prescribe a statin we always make sure the patient takes an ample amount of supplemental CoQ10 – at least 100 mg daily and taken with a meal.
4) Townsend Letter, Clearing Up the Cholesterol Confusion by Steven Sinatra, MD A well-known cardiologist explains why he doesn’t think lowering cholesterol is the answer for preventing heart disease, and debunks the routine prescription of statins for all but specific cases.
Effects of lovastatin on cognitive function and psychological well-being. Muldoon MF, Barger SD, Ryan CM, Flory JD, Lehoczky JP, Matthews KA, Manuck SB. Center for Clinical Pharmacology (MFM), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
CONCLUSION: Treatment of hypercholesterolemia with lovastatin did result in small performance decrements on neuropsychological tests of attention and psychomotor speed.
Lethal lipids-Heart Scan Blog William Davis MD
There’s a specific combination of lipids/lipoproteins that confers especially high risk for heart disease. That combination is:
Low HDL–generally less than 50 mg/dl
Small LDL–especially if 50% or more of total LDL
Lipoprotein(a)–an aggressive risk factor by itself
Total Cholesterol and Heart Disease
Dr Malcolm Kendrick (MbChB MRCGP) MD qualified in Aberdeen Scotland. He has worked in family practice for almost twenty years, and learned that treating patients is not like treating textbooks. He has specialized in heart disease and set up the on-line educational website for the European Society of Cardiology.
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The reader is advised to discuss the comments on these pages with
his/her personal physicians and to only act upon the advice of his/her personal physician. Also note that concerning an answer which appears as an electronically posted question, I am NOT creating a physician — patient relationship. Although identities will remain confidential as much as possible, as I can not control the media, I can not take responsibility for any breaches of confidentiality that may occur.
Mann, George V. “Diet-heart: end of an era.” New England Journal of Medicine 297.12 (1977): 644-650.
Heart Attack Prevention A History of Cardiovascular Disease Epidemiology U of Minnesota
“It Isn’t Always Fun.” – A Mann Apart A Biographical Story
Saturated fat and cholesterol in the diet are not the causes of coronary heart disease. That myth is the greatest scientific deception of this century, perhaps of any century.
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Disclaimer click here: http://www.drdach.com/wst_page20.html
The reader is advised to discuss the comments on these pages with his/her personal physicians and to only act upon the advice of his/her personal physician. Also note that concerning an answer which appears as an electronically posted question, I am NOT creating a physician — patient relationship.
Although identities will remain confidential as much as possible, as I can not control the media, I can not take responsibility for any breaches of confidentiality that may occur.
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